The Green Tree Frog was found in the Mackay area and sent north to Mission Beach for an operation to remove its extra leg.

Frog Safe founder Deborah Pergolotti says the amphibian is ready to return to the wild but that's easier said than done.

Under Queensland rules, rescued wildlife must be returned to their point of origin once they have recovered.

With people ordered to stay in their neighbourhoods and avoid non-essential travel, Ms Pergolotti was struggling to find anyone to take the frog home.

One volunteer has since come forward offering to deliver the frog to Mackay, but the trip won't be for another two weeks and many things could change in that time.

"The only reason she has to go back to Mackay is because the Queensland government requires it," she told AAP on Tuesday.

Ms Pergolotti says the amputee frog could make a new home in the animal sanctuary on her property south of Cairns, but that's not possible unless the government relaxes the rules.

It was initially thought the frog had a fifth leg growing out of her chest, but surgery revealed two legs were growing out of the same front socket - a deformity Ms Pergolotti has seen many times before.

"It was not quite accurately formed, it had toes on it but the wrong number, and it had an elbow joint, so it was moveable but it was pointing the wrong direction."

She wants rigorous research into a dramatic spike in malformed frogs, which she says coincided with the rise of neonicotinoid pesticides and insecticides in the late 1990s.

The European Union has banned outdoor use of neonicotinoids due to the serious danger they pose to bees.

The Australian Pesticides and Veterinary Medicines Authority is currently reviewing their use amid concerns about bee health.

Ms Pergolotti says deformed frogs began appearing in alarming numbers in the late 1990s, and there was a huge spike in 2003 when far north Queensland got drought-breaking rain.

She said reports of malformed frogs suddenly occurred en masse from different areas, including tadpoles with multiple limbs in their ponds, high die off rates, eggs that didn't hatch, and high rates of scoliosis, all of which "continues to this day".

"There's so little academic interest in what's going on with frogs. This research should be happening."

Australian Associated Press